In 1924, during her studies, she married Everett Chapman, but the couple divorced two years later. Margaret White added her mother’s surname, “Bourke” to her name in 1927 and hyphenated it.

One of Bourke-White’s clients was Otis Steel Company. Her success was due to her skills with both people and her technique. Her experience at Otis is a good example. As she explains in Portrait of Myself, the Otis security people were reluctant to let her shoot for many reasons. Firstly, steel making was a defense industry, so they wanted to be sure national security was not endangered. Second, she was a woman, and in those days, people wondered if a woman and her delicate cameras could stand up to the intense heat, hazard, and generally dirty and gritty conditions inside a steel mill. When she finally got permission, technical problems began. Black-and-white film in that era was sensitive to blue light, not the reds and oranges of hot steel, so she could see the beauty, but the photographs were coming out all black. She solved this problem by bringing along a new style of magnesium flare, which produces white light, and having assistants hold them to light her scenes. Her abilities resulted in some of the best steel factory photographs of that era, which earned her national attention.

In 1929, Bourke-White accepted a job as associate editor and staff photographer of Fortune magazine, a position she held until 1935. In 1930, she became the first Western photographer allowed to take photographs of Soviet industry. She was hired by Henry Luce as the first female photojournalist for Life magazine in 1936. She held the title of staff photographer until 1940, but returned from 1941 to 1942, and again in 1945, after which she stayed through her semi-retirement in 1957 (which ended her photography for the magazine) and her full retirement in 1969.

Her photographs of the construction of the Fort Peck Dam were featured in Life’s first issue, dated November 23, 1936, including the cover. This cover photograph became such a favorite that it was the 1930s’ representative in the United States Postal Service’s Celebrate the Century series of commemorative postage stamps. “Although Bourke-White titled the photo, ‘New Deal, Montana: Fort Peck Dam’, it is actually a photo of the spillway located three miles east of the dam,” according to a United States Army Corps of Engineers web page.

During the mid-1930s, Bourke-White, like Dorothea Lange, photographed drought victims of the Dust Bowl. In the February 15, 1937 issue of Life magazine, her famous photograph of black flood victims standing in front of a sign which declared, “World’s Highest Standard of Living”, showing a white family, was published. The photograph later would become the basis for the artwork of Curtis Mayfield’s 1975 album, ‘There’s No Place Like America Today’.